COVID-19 Steroid treatment

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COVID-19 have a suppressed immune response against the novel coronavirus rather than life-threatening hyper-inflammation, according to a study which suggests steroids such as dexamethasone should be reserved for the sickest patients. including those from St. Jude Children’s Research Hospital in the US, assessed the levels of the immune system protein cytokines, and other health markers in 168 adults with COVID-19, 26 adults with flu and 16 healthy volunteers.

Steroid treatment

Steroid treatment

published in the journal Science Advances, fewer than 5 per cent of the COVID-19 patients, including some of the sickest individuals, had the life-threatening, hyper inflammatory immune response known as the cytokine storm syndrome. They said more than 90 per cent of the COVID-19 patients were hospitalized, and about half in the intensive care unit (ICU), while more than half of flu patients were admitted for treatment, and 35 per cent were in the ICU. researchers explained that cytokine storms develop when excess or abnormally regulated levels of cytokine proteins in the body lead to hyper inflammation and tissue damage. While dexamethasone and other steroids are prescribed to treat cytokine storms, they said these drugs can backfire in patients whose immune response is already suppressed.

The need of the hour is a fast, reliable, and inexpensive test to measure cytokines and identify patients who are most likely to benefit from dexamethasone treatment. “Directing immunosuppressive therapies to the small subset of COVID-19 patients who have an overactive immune response is the only way to know if these approaches are ultimately helpful,” said Philip Mudd, another co-author of the study from the Washington University School of Medicine in the US.

COVID-19 patients with the broadly unregulated array of cytokines. But, overall, the average person with COVID-19 had less inflammation than the average person with flu,” said study co-author Paul Thomas from St. Jude Children’s Research Hospital. Based on the findings, the scientists said treatment suppressing inflammation might only be effective in a minority of patients with the hyper inflammatory profile.

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1 Reply to “COVID-19 Steroid treatment”

  1. Plasesays:

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